Current Problems in Cardiology
Volume 35, Issue 7 , Pages 314-376 , July 2010

Acute Pulmonary Embolism

References 

  1. Giuntini C, DiRicco G, Marini C, et al. Pulmonary embolism: epidemiology. Chest. 1995;107(suppl):3S–9S
  2. Stein PD, Hull RD, Patel KC, et al. Venous thromboembolic disease: comparison of the diagnostic process in men and women. Arch Intern Med. 2003;163:1689–1694
  3. Stein PD, Hull RD, Patel KC, et al. Venous thromboembolic disease: comparison of the diagnostic process in blacks and whites. Arch Intern Med. 2003;163:1843–1848
  4. Stein PD, Kayali F, Olson RE, et al. Pulmonary thromboembolism in Asian-Pacific islanders in the United States: analysis of ATA from the National Hospital discharge survey and the United States Bureau of the census. Am J Med. 2004;116:435–442
  5. Stein PD, Kayali F, Olson RE, et al. Pulmonary thromboembolism in American Indians and Alaskan natives. Arch Intern Med. 2004;164:1804–1806
  6. Stein PD, Hull RD, Kayali F, et al. Venous thromboembolism according to age: the impact of an aging population. Arch Intern Med. 2004;164:2260–2265
  7. Stein PD, Kayali F, Olson RE. Incidence of venous thromboembolism in infants and children: data from the National Hospital discharge survey. J Pediatr. 2004;145:563–565
  8. Stein PD, Kayali F, Olson RE. Analysis of occurrence of venous thromboembolic disease in the four seasons. Am J Cardiol. 2004;93:511–513
  9. Stein PD, Kayali F, Olson RE. Regional differences in rates of diagnosis and mortality of pulmonary thromboembolism. Am J Cardiol. 2004;93:1194–1197
  10. Stein PD. Pulmonary Embolism. 2nd edition. Oxford: Blackwell Futura; 2007;
  11. Havig O. Deep venous thrombosis and pulmonary embolism (Chapters 2, 4: Pulmonary thromboembolism). Acta Chir Scand. 1977;478(suppl):4–1124-37
  12. Neumann R. Ursprungszentren unde ntwicklungsformen der bein-thrombose. Virchow Arch Path Anat. 1938;301:708–735
  13. Stein PD, Henry JW. Prevalence of acute pulmonary embolism in central and subsegmental pulmonary arteries and relation to probability interpretation of ventilation/perfusion lung scans. Chest. 1997;111:1246–1248
  14. Stein PD, Fowler SE, Goodman LR, et al. PIOPED II Investigators Multidetector computed tomography for acute pulmonary embolism. N Engl J Med. 2006;354:2317–2327
  15. Stein PD. Wedge arteriography for the identification of pulmonary emboli in small vessels. Am Heart J. 1971;82:618–623
  16. Smith GT, Dammin GJ, Dexter L. Postmortem arteriographic studies of the human lung in pulmonary embolization. J Am Med Assoc. 1964;188:143–151
  17. Morrell MT, Dunnill MS. The post-mortem incidence of pulmonary embolism in a hospital population. Br J Surg. 1968;55:347–352
  18. Coon WW. The spectrum of pulmonary embolism: twenty years later. Arch Surg. 1976;111:398–402
  19. Byrne JJ. Phlebitis: a study of 748 cases at the Boston City Hospital. N Engl J Med. 1955;253:579–586
  20. Hermann RE, Davis JH, Holden WD. Pulmonary embolism: a clinical and pathologic study with emphasis on the effect of prophylactic therapywith anticoagulants. Am J Surg. 1961;102:19–28
  21. Collins R, Scrimgeour A, Yusuf S, et al. Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin (Overview of results of randomized trials in general, orthopedic, and urologic surgery). N Engl J Med. 1988;318:1162–1173
  22. Stein PD, Henry JW, Relyea B. Untreated patients with pulmonary embolism: outcome, clinical and laboratory assessment. Chest. 1995;107:931–935
  23. Stein PD, Kayali F, Olson RE. Estimated case fatality rate of pulmonary embolism, 1979-98. Am J Cardiol. 2004;93:1197–1199
  24. Carson JL, Kelley MA, Duff A, et al. The clinical course of pulmonary embolism. N Engl J Med. 1992;326:1240–1245
  25. Stein PD, Henry JW. Prevalence of acute pulmonary embolism among patients in a general hospital and at autopsy. Chest. 1995;108:978–981
  26. The Columbus Investigators. Low-molecular-weight heparin in the treatment of patients with venous thromboembolism. N Engl J Med. 1997;337:657–662
  27. Simonneau G, Sors H, Charbonnier B, et al. A comparison of low-molecular-weight heparin with unfractionated heparin for acute pulmonary embolism (The THESSE Study Group). N Engl J Med. 1997;337:663–669
  28. Stein PD, Beemath A, Matta F, et al. Clinical characteristics of patient with acute pulmonary embolism: data from PIOPED II. Am J Med. 2007;120:871–879
  29. Stein PD, Terrin ML, Hales CA, et al. Clinical, laboratory, roentgenographic and electrocardiographic findings in patients with acute pulmonary embolism and no pre-existing cardiac or pulmonary disease. Chest. 1991;100:598–603
  30. Beemath A, Stein PD, Skaf E, et al. Risk of venous thromboembolism in patients hospitalized with heart failure. Am J Cardiol. 2006;98:793–795
  31. Howell MD, Geraci JM, Knowlton AA. Congestive heart failure and outpatient risk of venous thromboembolism: a retrospective, case-control study. J Clin Epidemiol. 2001;54:810–816
  32. Stein PD, Beemath A, Meyers FA, et al. Incidence of venous thromboembolism in patients hospitalized with cancer. Am J Med. 2006;119:60–68
  33. Skaf E, Stein PD, Beemath A, et al. Venous thromboembolism in patients with ischemic and hemorrhagic stroke. Am J Cardiol. 2005;96:1731–1733
  34. Stein PD, Beemath A, Meyers FA, et al. Pulmonary embolism and deep venous thrombosis in patients hospitalized with chronic obstructive pulmonary disease. J Cardiovasc Med. 2007;8:253–257
  35. Stein PD, Hull RD, Kayali F, et al. Venous thromboembolism in pregnancy: 21 year trends. Am J Med. 2004;117:121–125
  36. Stein PD, Beemath A, Olson RE. Obesity as a risk factor in venous thromboembolism. Am J Med. 2005;118:978–980
  37. Stein PD, Beemath A, Meyers FA, et al. Deep venous thrombosis and pulmonary embolism in patients hospitalized with sickle cell disease. Am J Med. 2006;119:897–901
  38. Kayali F, Najjar R, Aswad F, et al. Venous thromboembolism in patients hospitalized with nephrotic syndrome. Am J Med. 2008;121:226–230
  39. Matta F, Yaekoub AY, Stein PD. Human immunodeficiency virus infection and risk of venous thromboembolism. Am J Med Sci. 2008;336:402–406
  40. Stein PD, Goldman J, Matta F, et al. Diabetes mellitus and risk of venous thromboembolism. Am J Med Sci. 2009;337:259–264
  41. Matta F, Singala R, Yaekoub AY, et al. Risk of venous thromboembolism with rheumatoid arthritis. Thromb Haemost. 2009;101:134–138
  42. Danescu L, Badshah A, Danescu SC, et al. Venous thromboembolism in patients hospitalized with thyroid dysfunction. Clin Appl Thromb Hemost. 2009;15:676–680
  43. Lewis MA. The epidemiology of oral contraceptive use: a critical review of the studies on oral contraceptives and the health of young women. Am J Obstet Gynecol. 1998;179:1086–1097
  44. Jick SS, Kaye JA, Russmann S, et al. Risk of nonfatal venous thromboembolism in women using a contraceptive transdermal patch and oral contraceptives containing norgestimate and 35 microg of ethinyl estradiol. Contraception. 2006;73:223–228
  45. Realini JP, Goldzieher JW. Oral contraceptives and cardiovascular disease: a critique of the epidemiologic studies. Am J Obstet Gynecol. 1985;152:729–798
  46. Vandenbroucke JP, Rosing J, Bloemenkamp KW, et al. Oral contraceptives and the risk of venous thrombosis. N Engl J Med. 2001;344:1527–1535
  47. Stein PD, Matta F, Musani M, et al. Silent pulmonary embolism in patients with deep venous thrombosis: a systematic review. Am J Med. 2010;123:426–431
  48. The Urokinase Pulmonary Embolism Trial. A national cooperative study (Associated laboratory and clinical findings). Circulation. 1973;47/48(suppl II):II81–II85
  49. A collaborative study by the PIOPED Investigators. Value of the ventilation-perfusion scan in acute pulmonary embolism: results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). J Am Med Assoc. 1990;263:2753–2759
  50. Stein PD, Hull RD, Ghali WA, et al. Tracking the uptake of evidence: two decades of hospital practice trends for diagnosing deep venous thrombosis and pulmonary embolism. Arch Intern Med. 2003;163:1213–1219
  51. Stein PD, Willis PW, DeMets DL. History and physical examination in acute pulmonary embolism in patients without pre-existing cardiac or pulmonary disease. Am J Cardiol. 1981;47:218–223
  52. Stein PD, Afzal A, Henry JW, et al. Fever in acute pulmonary embolism. Chest. 2000;117:39–42
  53. Stein PD, Saltzman HA, Weg JG. Clinical characteristics of patients with acute pulmonary embolism. Am J Cardiol. 1991;68:1723–1724
  54. Stein PD, Henry JW. Clinical characteristics of patients with acute pulmonary embolism stratified according to their presenting syndromes. Chest. 1997;112:974–979
  55. Stein PD, Goldhaber SZ, Henry JW, et al. Arterial blood gas analysis in the assessment of suspected acute pulmonary embolism. Chest. 1996;109:78–81
  56. Stein PD, Goldhaber SZ, Henry JW. Alveolar-arterial oxygen gradient in the assessment of acute pulmonary embolism. Chest. 1995;107:139–143
  57. Stein PD, Dalen JE, McIntyre KM, et al. The electrocardiogram in acute pulmonary embolism. Prog Cardiovasc Dis. 1975;17:247–257
  58. Horn H, Dack S, Friedberg CK. Cardiac sequelae of embolism of the pulmonary artery. Arch Intern Med. 1939;64:296–321
  59. Dack S, Master AM, Horn H, et al. Acute coronary insufficiency due to pulmonary embolism. Am J Med. 1949;7:464–477
  60. Stein PD, Alshabkhoun S, Hatem C, et al. Coronary artery blood flow in acute pulmonary embolism. Am J Cardiol. 1968;21:32–37
  61. Stein PD, Alshabkhoun S, Hawkins HF, et al. Right coronary blood flow in acute pulmonary embolism. Am Heart J. 1969;77:356–362
  62. Lynch RE, Stein PD, Bruce TA. Leftward shift of frontal plane QRS axis as a frequent manifestation of acute pulmonary embolism. Chest. 1972;61:443–446
  63. Stein PD, Willis PW, DeMets DL, et al. Plain chest roentgenogram in patients with acute pulmonary embolism and no pre-existing cardiac or pulmonary disease. Am J Noninvas Cardiol. 1987;1:171–176
  64. Cheriex EC, Sreeram N, Eussen YF, et al. Cross sectional Doppler echocardiography as the initial technique for the diagnosis of acute pulmonary embolism. Br Heart J. 1994;72:52–57
  65. Kasper W, Meinertz T, Henkel B, et al. Echocardiographic findings in patients with proved pulmonary embolism. Am Heart J. 1986;112:1284–1290
  66. Franzoni P, Cuccia C, Zappa C, et al. Thromboembolus migrating into the right heart in pulmonary embolism (Echocardiographic and clinicotherapeutic aspects in 7 cases and review of the literature). G Ital Cardiol. 1989;19:7–16
  67. Casazza F, Bongarzoni A, Centonze F, et al. Prevalence and prognostic significance of right-sided cardiac mobile thrombi in acute massive pulmonary embolism. Am J Cardiol. 1997;79:1433–1435
  68. Castillo-Fenoy A, Scheuble C, Benacerraf A, et al. Echographical symptomatology of acute pulmonary embolism. Arch Mal Coeur Vaiss. 1980;73:971–978
  69. Chapoutot L, Metz D, Canivet E, et al. Mobile thrombus of the right heart and pulmonary embolism: diagnostic and therapeutic problems (Apropos of 12 cases). Arch Mal Coeur Vaiss. 1993;86:1039–1045
  70. Sanson BJ, Lijmer JG, Mac Gillavry MR, et al. ANTELOPE-Study Group Comparison of a clinical probability estimate and two clinical models in patients with suspected pulmonary embolism. Thromb Haemost. 2000;83:199–203
  71. Wicki J, Pernerger TV, Junod AF, et al. Assessing clinical probability of pulmonary embolism in the emergency ward: a simple score. Arch Intern Med. 2001;161:92–97
  72. Wells PS, Anderson DR, Rodger M, et al. Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and D-dimer. Ann Intern Med. 2001;135:98–107
  73. Wells PS, Anderson DR, Rodger M, et al. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer. Thromb Haemost. 2000;83:416–420
  74. Le Gal G, Righini M, Roy P-M, et al. Prediction of pulmonary embolism in the emergency department: the revised Geneva score. Ann Intern Med. 2006;144:165–171
  75. van Belle A, Buller HR, Huisman MV, et al. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. J Am Med Assoc. 2006;295:172–179
  76. Ollenberger GP, Worsley DF. Effect of patient location on the performance of clinical models to predict pulmonary embolism. Thromb Res. 2006;118:685–690
  77. Miniati M, Monti S, Bottai M. A structured clinical model for predicting the probability of pulmonary embolism. Am J Med. 2003;114:173–179
  78. Kline JA, Courtney DM, Kabrhel C, et al. Prospective multicenter evaluation of the pulmonary embolism rule-out criteria. J Thromb Haemost. 2008;6:772–780
  79. Stein PD, Hull RD, Patel KC, et al. D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: a systematic review. Ann Intern Med. 2004;140:589–602
  80. Di Nisio M, Squizzato A, Rutjes AW, et al. Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic review. J Thromb Haemost. 2007;5:296–304
  81. Perrier A, Roy PM, Sanchez O, et al. Multidetector-row computed tomography in suspected pulmonary embolism. N Engl J Med. 2005;28:1760–1768
  82. Stein PD, Woodard PK, Weg JG, et al. Diagnostic pathways in acute pulmonary embolism: recommendations of the PIOPED II investigators. Am J Med. 2006;119:1048–1055
  83. de Monye W, Sanson BJ, Buller HR, et al. The performance of two rapid quantitative D-dimer assays in 287 patients with clinically suspected pulmonary embolism. Thromb Res. 2002;107:283–286
  84. Galle C, Papazyan JP, Miron MJ, et al. Prediction of pulmonary embolism extent by clinical findings, D-dimer level and deep vein thrombosis shown by ultrasound. Thromb Haemost. 2001;86:1156–1160
  85. Chabloz P, Reber G, Boehlen F, et al. Tafi antigen and D-dimer levels during normal pregnancy and at delivery. Br J Haematol. 2001;115:150–152
  86. Righini M, Goehring C, Bounameaux H, et al. Effects of age on the performance of common diagnostic tests for pulmonary embolism. Am J Med. 2000;109:357–361
  87. Barro C, Bosson JL, Pernod G, et al. Plasma D-dimer testing improves the management of thromboembolic disease in hospitalized patients. Thromb Res. 1999;95:263–269
  88. Di Nisio M, Sohne M, Kamphuisen PW, et al. D-dimer test in cancer patients with suspected acute pulmonary embolism. J Thromb Haemost. 2005;3:1239–1242
  89. Schrecengost JE, LeGallo RD, Boyd JC, et al. Comparison of diagnostic accuracies in outpatients and hospitalized patients of D-dimer testing for the evaluation of suspected pulmonary embolism. Clin Chem. 2003;49:1483–1490
  90. Le Gal G, Righini M, Roy PM, et al. Value of D-dimer testing for the exclusion of pulmonary embolism in patients with previous venous thromboembolism. Arch Intern Med. 2006;166:176–180
  91. Hull RD, Raskob GE, Ginsberg JS, et al. Noninvasive strategy for the treatment of patients with suspected pulmonary embolism. Arch Intern Med. 1994;154:289–297
  92. Wells PS, Ginsberg JS, Anderson DR, et al. Use of a clinical model for safe management of patients with suspected pulmonary embolism. Ann Intern Med. 1998;129:997–1005
  93. Gottschalk A, Sostman HD, Coleman RE, et al. Ventilation-perfusion scintigraphy in the PIOPED study (part II. Evaluation of the scintigraphic criteria and interpretations). J Nucl Med. 1993;34:1119–1126
  94. Sostman HD, Coleman RE, DeLong DM, et al. Evaluation of revised criteria for ventilation-perfusion scintigraphy in patients with suspected pulmonary embolism. Radiology. 1994;193:103–107
  95. Miniati M, Pistolesi M, Marini C, et al. Value of perfusion lung scan in the diagnosis of pulmonary embolism: results of the prospective investigative study of acute pulmonary embolism diagnosis (PISA-PED). Am J Respir Crit Care Med. 1996;154:1387–1393
  96. Stein PD, Gottschalk A. Review of criteria appropriate for a very low probability of pulmonary embolism on ventilation-perfusion lung scans: a position paper. Radiographics. 2000;20:99–105
  97. Stein PD, Henry JW, Gottschalk A. Mismatched vascular defects: an easy alternative to mismatched segmental equivalent defects for the interpretation of ventilation/perfusion lung scans in pulmonary embolism. Chest. 1993;104:1468–1471
  98. Stein PD, Gottschalk A, Henry JW, et al. Stratification of patients according to prior cardiopulmonary disease and probability assessment based on the number of mismatched segmental equivalent perfusion defects (Approaches to strengthen the diagnostic value of ventilation/perfusion lung scans in acute pulmonary embolism). Chest. 1993;104:1461–1467
  99. Stein PD, Henry JW, Gottschalk A. The addition of clinical assessment to stratification according to prior cardiopulmonary disease further optimizes the interpretation of ventilation/perfusion lung scans in pulmonary embolism. Chest. 1993;104:1472–1476
  100. Sostman HD, Miniati M, Gottschalk A, et al. Sensitivity and specificity of perfusion scintigraphy combined with chest radiography for acute pulmonary embolism in PIOPED II. J Nucl Med. 2008;49:1741–1748
  101. Stein PD, Freeman LM, Sostman HD, et al. SPECT in acute pulmonary embolism. J Nucl Med. 2009;50:1999–2007
  102. Leblanc M, Leveill̇ee F, Turcotte E. Prospective evaluation of the negative predictive value of V/Q SPECT using 99mTc-technegas. Nucl Med Commun. 2007;28:667–672
  103. Miles S, Rogers KM, Thomas P, et al. Al. A comparison of SPECT lung scintigraphy and CTPA for the diagnosis of pulmonary embolism. Chest. 2009;136:1546–1553
  104. Bajc M, Olsson CG, Olsson B, et al. Diagnostic evaluation of planar and tomographic ventilation/perfusion lung images in patients with suspected pulmonary emboli. Clin Physiol Funct Imaging. 2004;24:249–256
  105. Collart JP, Roelants V, Vanpee D, et al. Is a lung perfusion scan obtained by using single photon emission computed tomography able to improve the radionuclide diagnosis of pulmonary embolism?. Nucl Med Commun. 2002;23:1107–1113
  106. Reinartz P, Wildberger JE, Schaefer W, et al. Tomographic imaging in the diagnosis of pulmonary embolism: a comparison between V/Q lung scintigraphy in SPECT technique and multislice spiral CT. J Nucl Med. 2004;45:1501–1508
  107. Reid JH, Coche EE, Inoue T, et al. International Atomic Energy Agency Consultants' group Is the lung scan alive and well? (Facts and controversies in defining the role of lung scintigraphy for the diagnosis of pulmonary embolism in the era of MDCT). Eur J Nucl Med Mol Imaging. 2009;36:505–521
  108. Stein PD, Athanasoulis C, Alavi A, et al. Complications and validity of pulmonary angiography in acute pulmonary embolism. Circulation. 1992;85:462–468
  109. Meister SG, Brooks HL, Szucs MM, et al. Pulmonary cineangiography in acute pulmonary embolism. Am Heart J. 1972;84:33–37
  110. Ferris EJ, Holder JC, Lim WN, et al. Angiography of pulmonary emboli: digital studies and balloon occlusion cineangiography. AJR Am J Roentgenol. 1984;142:369–373
  111. Stein PD, Kayali F, Hull RD. Spiral CT, for the diagnosis of acute pulmonary embolism. Thromb Haemost. 2007;98:713–720
  112. Stein PD, Beemath A, Goodman LR, et al. Outcome studies of pulmonary embolism vs accuracy: they do not equate. Thromb Haemost. 2006;96:107–108
  113. Meaney JF, Weg JG, Chenevert TL, et al. Diagnosis of pulmonary embolism with magnetic resonance angiography. N Engl J Med. 1997;336:1422–1427
  114. Gupta A, Frazer CK, Ferguson JM, et al. Acute pulmonary embolism: diagnosis with MR angiography. Radiology. 1999;210:353–359
  115. Loubeyre P, Revel D, Douek P, et al. Dynamic contrast-enhanced MR angiography of pulmonary embolism: comparison with pulmonary angiography. AJR Am J Roentgenol. 1994;162:1035–1039
  116. Ohno Y, Higashino T, Takenaka D, et al. MR angiography with sensitivity encoding (SENSE) for suspected pulmonary embolism: comparison with MDCT and ventilation-perfusion scintigraphy. AJR Am J Roentgenol. 2004;183:91–98
  117. Pleszewski B, Chartrand-Lefebvre C, Qanadli SD, et al. Gadolinium-enhanced pulmonary magnetic resonance angiography in the diagnosis of acute pulmonary embolism: a prospective study on 48 patients. Clin Imaging. 2006;30:166–172
  118. Kluge A, Luboldt W, Bachmann G. Acute pulmonary embolism to the subsegmental level: diagnostic accuracy of three MRI techniques compared with 16-MDCT. AJR Am J Roentgenol. 2006;187:W7–W14
  119. Ersoy H, Goldhaber SZ, Cai T, et al. Time-resolved MR angiography: a primary screening examination of patients with suspected pulmonary embolism and contraindications to administration of iodinated contrast material. AJR Am J Roentgenol. 2007;188:1246–1254
  120. Blum A, Bellou A, Guillemin F, et al. GENEPI study group Performance of magnetic resonance angiography in suspected acute pulmonary embolism. Thromb Haemost. 2005;93:503–511
  121. Oudkerk M, van Beek EJR, Weilopolski P, et al. Comparison of contrast-enhanced magnetic resonance angiography and conventional pulmonary angiography for the diagnosis of pulmonary embolism: a prospective study. Lancet. 2002;359:1643–1647
  122. Sampson FC, Goodacre SW, Thomas SM, et al. The accuracy of MRI in diagnosis of suspected deep vein thrombosis: systematic review and meta-analysis. Eur Radiol. 2007;17:175–181
  123. Kluge A, Mueller C, Strunk J, et al. Experience in 207 combined MRI examinations for acute pulmonary embolism and deep vein thrombosis. AJR Am J Roentgenol. 2006;186:1686–1696
  124. Stein PD, Gottschalk A, Sostman HD, et al. Methods of prospective investigation of pulmonary embolism diagnosis III (PIOPED III). Semin Nucl Med. 2008;38:462–470
  125. US Food and Drug Administration. Healthcare professional sheet (Gadolinium-containing contrast agents for magnetic resonance imaging (MRI) (marketed as Omniscan, Optimark, Magnevist, prohance and Multihance)). http://www.fda.gov/cder/drug/InfoSheets/HCP/gccaHCP.htmAccessed November 2, 2009
  126. Cowper SE. International Center for Nephrogenic Fibrosing Dermopathy Research (ICNFDR). http://www.pathmax.com/dermweb/Accessed October 27, 2009
  127. Goodman LR, Stein PD, Matta F, et al. CT venography and compression sonography are diagnostically equivalent: data from PIOPED II. AJR Am J Roentgenol. 2007;189:1071–1076
  128. Goodman LR, Stein PD, Beemath A, et al. CT venography for deep venous thrombosis: continuous images vs reformatted discontinuous images using PIOPED II data. AJR Am J Roentgenol. 2007;189:409–412
  129. Stein PD, Matta F, Yaekoub AY, et al. CT venous phase venography with 64-slice CT angiography in the diagnosis of acute pulmonary embolism. Clin Appl Thromb/Hemost. 2009;[Epub ahead of print]
  130. Mayo JR, Aldrich J, Müller NL. Radiation exposure at chest CT: a statement of the Fleischner Society. Radiology. 2003;228:15–21
  131. ICRP. Annals of the International Commission of Radiological Protection (ICRP) International Commission on Radiological Protection. Publications 1990;60. Recommendations of the International Commission on Radiological Protection, 60 Ann ICRP. 1991;21:1–3
  132. Robinson A. Radiation protection and patient doses in diagnostic radiology. In:  Grainger RG,  Allison D editor. Grainger and Allison's Diagnostic Radiology. 3rd edition. New York: Churchill Livingstone; 1997;p. 169–183
  133. Kuiper JW, Geleijns J, Matheijssen NAA, et al. Radiation exposure of multi-row detector spiral computed tomography of the pulmonary arteries: comparison with digital subtraction pulmonary angiography. Eur Radiol. 2003;13:1496–1500
  134. O'Neill J, Murchison JT, Wright L, et al. Effect of the introduction of helical CT on radiation dose in the investigation of pulmonary embolism. Br J Radiol. 2005;78:46–50
  135. Resten A, Mausoleo F, Valero M, et al. Comparison of doses for pulmonary embolism detection with helical CT and pulmonary angiography. Eur Radiol. 2003;13:1515–1521
  136. Wittram C, Liu B, Callahan RJ, et al. An estimate of the radiation dose received per patient for the investigation of pulmonary venous thromboembolism based on the PIOPED II data [abstract 4408707]. In: Presented at the Radiol Soc North Am. Chicago, IL. November 2005;
  137. Huda W, Sourkes AM. Radiation doses from chest X-rays in Manitoba (1979 and 1987). Radiat Prot Dosim. 1989;28:303–308
  138. Parker MS, Hui FK, Camacho MA. Female breast radiation exposure during CT pulmonary angiography. AJR Am J Roentgenol. 2005;185:1228–1233
  139. Cook JV, Kyriou J. Radiation from CT and perfusion scanning in pregnancy. BMJ. 2005;331:350
  140. Milne EN. Female breast radiation exposure. AJR Am J Roentgenol. 2006;186:E24
  141. Einstein AJ, Henzlova MJ, Rajagopalan S. Estimating risk of cancer associated with radiation exposure from 64-slice computed tomography coronary angiography. J Am Med Assoc. 2007;298:317–323
  142. Brenner DJ, Hall EJ. Computed tomography-an increasing source of radiation exposure. N Engl J Med. 2007;357:2277–2284
  143. Radiation dose to patients from radiopharmaceuticals (addendum 2 to ICRP publication 53). Ann ICRP. 1998;28:1–126
  144. Le Gal G, Bounameaux H. Diagnosing pulmonary embolism: running after the decreasing prevalence of cases among suspected patients. J Thromb Haemost. 2004;2:1244–1246
  145. Amis ES, Butler PF, Applegate KE, et al. American College of Radiology American College of Radiology white paper on radiation dose in medicine. J Am Coll Radiol. 2007;4:272–284
  146. Geerts WH, Heit JA, Clagett GP, et al. Prevention of venous thromboembolism. Chest. 2001;119:132S–175S
  147. Cohen AT, Tapson VF, Bergmann JF, et al. ENDORSE Investigators Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet. 2008;371:387–394
  148. Kucher N, Koo S, Quiroz R, et al. Electronic alerts to prevent venous thromboembolism among hospitalized patients. N Engl J Med. 2005;352:969–977
  149. Piazza G, Rosenbaum EJ, Pendergast W, et al. Physician alerts to prevent symptomatic venous thromboembolism in hospitalized patients. Circulation. 2009;119:2196–2201
  150. Geerts WH, Bergqvist D, Pineo GF, et al. American College of Chest Physicians Prevention of Venous Thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, 8th edition. Chest. 2008;133:381S–453
  151. Hirsh J, Bauer KA, Donati MB, et al. American College of Chest Physicians Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, 8th edition. Chest. 2008;133(suppl 6):141S–159
  152. Warkentin TE, Greinacher A, Koster A, et al. American College of Chest Physicians Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, 8th edition. Chest. 2008;133(suppl 6):340S–380S
  153. Stein PD, Hull RD, Matta F, et al. Incidence of thrombocytopenia in hospitalized patients with venous thromboembolism. Am J Med. 2009;122:919–930
  154. Bauer KA. The thrombophilias: well-defined risk factors with uncertain therapeutic implications. Ann Intern Med. 2001;135:367–373
  155. Dalen JE. Should patients with venous thromboembolism be screened for thrombophilia?. Am J Med. 2008;121:458–463
  156. Kahn SR, Elman E, Rodger MA, et al. Use of elastic compression stockings after deep venous thrombosis: a comparison of practices and perceptions of thrombosis physicians and patients. J Thromb Haemost. 2003;1:500–506
  157. Kearon C, Kahn SR, Agnelli G, et al. American College of Chest Physicians Antithrombotic Therapy for Venous Thromboembolic Disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [8th edition]. Chest. 2008;133:454S–545
  158. Musani M, Matta F, Yaekoub AY, et al. Venous compression in the prevention of post-thrombotic syndrome. Am J Med (In Press).
  159. Brandjes DP, Büller HR, Heijboer H, et al. Randomized trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis. Lancet. 1997;349:759–762
  160. Ginsberg JS, Hirsh J, Julian J, et al. Prevention and treatment of postphlebitic syndrome: results of a 3-part study. Arch Intern Med. 2001;161:2105–2109
  161. Partsch H, Kaulich M, Mayer W. Immediate mobilisation in acute vein thrombosis reduces post-thrombotic syndrome. Int Angiol. 2004;23:206–212
  162. Prandoni P, Lensing AW, Prins MH, et al. Below-knee elastic compression stockings to prevent the post-thrombotic syndrome: a randomized, controlled trial. Ann Intern Med. 2004;141:249–256
  163. Aschwanden M, Jeanneret C, Koller MT, et al. Effect of prolonged treatment with compression stockings to prevent post-thrombotic sequelae: a randomized controlled trial. J Vasc Surg. 2008;47:1015–1021
  164. Stein PD, Yaekoub AY, Ahsan ST, et al. Ankle exercise and venous blood velocity. Thromb Haemost. 2009;101:1100–1103
  165. Stein PD, Matta F, Yaekoub AY, et al. Effect of compression stockings on venous blood velocity. Thromb Haemost. 2010;103:138–144
  166. Stein PD, Hull RD, Matta F, et al. Anticoagulants for acute venous thromboembolism: what we think we know and what the data show for timing of recurrent events. Clin Appl Thromb Hemost. 2009;15:609–612
  167. Brandjes DP, Heijboer H, Büller HR, et al. Acenocoumarol and heparin compared with acenocoumarol alone in the initial treatment of proximal-vein thrombosis. N Engl J Med. 1992;327:1485–1489
  168. Hull RD, Raskob GE, Brant RF, et al. Relation between the time to achieve the lower limit of the APTT therapeutic range and recurrent venous thromboembolism during heparin treatment for deep vein thrombosis. Arch Intern Med. 1997;157:2562–2568
  169. Prandoni P, Carnovali M, Marchiori A Galilei Investigators. Subcutaneous adjusted-dose unfractionated heparin vs fixed-dose low-molecular-weight heparin in the initial treatment of venous thromboembolism. Arch Intern Med. 2004;164:1077–1083
  170. Basu D, Gallus A, Hirsh J, et al. A prospective study of the value of monitoring heparin treatment with the activated partial thromboplastin time. N Engl J Med. 1972;287:324–327
  171. Stein PD, Hull RD, Matta F, et al. Early discharge of patients with venous thromboembolism: implications regarding therapy. Clin Appl Thromb Hemost. 2010;16:141–145
  172. Aujesky D, Stone RA, Kim S, et al. Length of hospital stay and postdischarge mortality in patients with pulmonary embolism: a statewide perspective. Arch Intern Med. 2008;168:706–712
  173. Koopman MM, Prandoni P, Piovella F, et al. Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home (The Tasman Study Group). N Engl J Med. 1996;334:682–687
  174. Levine M, Gent M, Hirsh J, et al. A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis. N Engl J Med. 1996;334:677–681
  175. Douketis JD, Kearon C, Bates S, et al. Risk of fatal pulmonary embolism in patients with treated venous thromboembolism. J Am Med Assoc. 1998;279:458–462
  176. Ageno W, Steidl L, Marchesi C, et al. Selecting patients for home treatment of deep vein thrombosis: the problem of cancer. Haematologica. 2002;87:286–291
  177. Janjua M, Badshah A, Matta F, et al. Treatment of acute pulmonary embolism in outpatients or following early discharge: a systematic review. Thromb Haemost. 2008;100:756–761
  178. Wessler S, Morris LE. Studies in intravascular coagulation IV (The effect of heparin and dicumarol on serum-induced venous thrombosis). Circulation. 1955;12:553–556
  179. Nicholls SC, O'Brian JK, Sutton MG. Venous thromboembolism: detection by duplex scanning. J Vasc Surg. 1996;23:511–516
  180. Marin HM, Stefanini M. Experimental production of phlebothrombosis. Surg Gynecol Obstet. 1960;110:263–268
  181. Wessler S, Gitel SN. Warfarin from bedside to bench. N Engl J Med. 1984;311:645–652
  182. Zivelin A, Rao LV, Rapaport SI. Mechanism of the anticoagulant effect of warfarin as evaluated in rabbits by selective depression of individual procoagulant vitamin K-dependent clotting factors. J Clin Invest. 1993;92:2131–2140
  183. Harrison L, Johnston M, Massicotte MP, et al. Comparison of 5-mg and 10-mg loading doses in initiation of warfarin therapy. Ann Intern Med. 1997;126:133–136
  184. White RH, Zhou H, Romano PS. Length of hospital stay for treatment of deep venous thrombosis and the incidence of recurrent thromboembolism. Arch Intern Med. 1998;158:1005–1010
  185. Kearon C, Ginsberg JS, Kovacs MJ, et al. Extended Low-Intensity Anticoagulation for Thrombo-Embolism Investigators Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism. N Engl J Med. 2003;349:631–639
  186. Ridker PM, Goldhaber SZ, Danielson E, et al. PREVENT Investigators Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism. N Engl J Med. 2003;348:1425–1434
  187. Palareti G, Cosmi B, Legnani C, et al. PROLONG Investigators D-dimer testing to determine the duration of anticoagulation therapy. N Engl J Med. 2006;355:1780–1789
  188. Stein PD, Hull RD, Raskob GE. Risk of withholding treatment of acute pulmonary embolism in patients with negative serial noninvasive leg tests and adequate cardiorespiratory reserve. Am J Med. 2000;109:301–306
  189. Yalamanchili K, Sukhija R, Aronow WS, et al. Prevalence of increased cardiac troponin I levels in patients with and without acute pulmonary embolism and relation of increased cardiac troponin I levels with in-hospital mortality in patients with acute pulmonary embolism. Am J Cardiol. 2004;93:263–264
  190. Konstantinides S, Geibel A, Olschewski M, et al. Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism. Circulation. 2002;106:1263–1268
  191. Kucher N, Wallmann D, Carone A, et al. Incremental prognostic value of troponin I and echocardiography in patients with acute pulmonary embolism. Eur Heart J. 2003;24:1651–1656
  192. La Vecchia L, Ottani F, Favero L, et al. Increased cardiac troponin I on admission predicts in-hospital mortality in acute pulmonary embolism. Heart. 2004;90:633–637
  193. Scridon T, Scridon C, Skali H, et al. Prognostic significance of troponin elevation and right ventricular enlargement in acute pulmonary embolism. Am J Cardiol. 2005;96:303–305
  194. Kucher N, Goldhaber SZ. Cardiac biomarkers for risk stratification of patients with acute pulmonary embolism. Circulation. 2003;108:2191–2194
  195. Tulevski II, Hirsch A, Sanson BJ, et al. Increased brain natriuretic peptide as a marker for right ventricular dysfunction in acute pulmonary embolism. Thromb Haemost. 2001;86:1193–1196
  196. Kucher N, Printzen G, Doernhoefer T, et al. Low pro-brain natriuretic peptide levels predict benign clinical outcome in acute pulmonary embolism. Circulation. 2003;107:1576–1578
  197. Cannon CP, Goldhaber SZ. Cardiovascular risk stratification of pulmonary embolism. Am J Cardiol. 1996;78:1149–1151
  198. Goldhaber SZ. Thrombolysis in pulmonary embolism (A large-scale clinical trial is overdue). Circulation. 2001;104:2876–2878
  199. Leacche M, Unic D, Goldhaber SZ, et al. Modern surgical treatment of massive pulmonary embolism: results in 47 consecutive patients after rapid diagnosis and aggressive surgical approach. J Thorac Cardiovasc Surg. 2005;129:1018–1023
  200. Stein PD, Beemath A, Matta F, et al. Enlarged right ventricle without shock in acute pulmonary embolism: prognosis. Am J Med. 2008;121:34–42
  201. Stein PD, Matta F, Yaekoub AY, et al. Resolution of the CT pulmonary angiogram. AJR Am J Roentgenol. 2010;194:1263–1268
  202. Skaf E, Beemath A, Siddiqui T, et al. Catheter embolectomy in the management of massive pulmonary embolism. Am J Cardiol. 2007;99:415–420
  203. Buller HR, Agnelli G, Hull RD, et al. Antithrombotic therapy for venous thromboembolic disease: the Seventh ACCP Conference on antithrombotic and thrombolytic therapy. Chest. 2004;126(suppl):401S–428
  204. Stein PD, Alnas M, Beemath A, et al. Outcome of pulmonary embolectomy. Am J Cardiol. 2007;99:421–423
  205. Stein PD, Kayali F, Olson RE. Trends over 21 years in the use of vena cava filters. Arch Intern Med. 2004;164:1541–1545
  206. Stein PD, Alnas M, Skaf E, et al. Outcome and complications of retrievable inferior vena cava filters. Am J Cardiol. 2004;94:1090–1093
  207. Stein PD, Chenevert TL, Fowler SE, et al. PIOPED III Investigators Gadolinium enhanced magnetic resonance angiography for acute pulmonary embolism: Results of the PIOPED III Trial. Ann Intern Med. 2010;152:434–443

PII: S0146-2806(10)00040-X

doi: 10.1016/j.cpcardiol.2010.03.002

Current Problems in Cardiology
Volume 35, Issue 7 , Pages 314-376 , July 2010