Current Problems in Cardiology
Volume 33, Issue 5 , Pages 203-277 , May 2008

Thoracic Aortic Aneurysm: Reading the Enemy's Playbook

References 

  1. Elefteriades JA. Preface. In:  Elefteriades JA editors. Diseases of the aorta (Cardiol Clin). 17:1999;i-850.
  2. Anagnostopoulos CE. Acute aortic dissections. Baltimore, MD: University Park Press; 1975;
  3. Tittle SL, Lynch RJ, Cole PE, et al. Midterm follow-up of penetrating ulcer and intramural hematoma of the aorta. J Thorac Cardiovasc Surg. 2002;123:1051–1059
  4. Motoyoshi N, Moizumi Y, Komatsu T, et al. Intramural hematoma and dissection involving ascending aorta: the clinical features and prognosis. Eur J Cardiothorac Surg. 2003;24(2):237–242discussion 242.
  5. Scott RA, Wilson NM, Ashton HA, et al. Influence of screening on the incidence of ruptured abdominal aortic aneurysm: 5-year results of a randomized controlled study. Br J Surg. 1995;82:1066–1070
  6. Golledge J, Muller J, Daugherty A, et al. Abdominal aortic aneurysm. Pathogenesis and implications Arterioscler Thormb Vasc Biol. 2006;Epub ahead of print.
  7. Acosta S, Ogren M, Bengtsson H, et al. Increasing incidence of ruptured abdominal aortic aneurysm: a population-based study. J Vasc Surg. 2006;44:237–243
  8. Clouse WWE, Hallett JW, Schaff HV, et al. Improved prognosis of thoracic aortic aneurysms: a population-based study. JAMA. 1998;280:1926–1929
  9. Elefteriades JA, Rizzo JA. Epidemiology: Incidence, Prevalence, Trends in Elefteriades, JA (ed): Acute Aortic Conditions. Informa Healthcare. New York 2007.
  10. Johansson G, Markstrom U, Swedenborg J. Ruptured thoracic aortic aneurysms: a study of incidence and mortality rates. J Vasc Surg. 1995;21:985–988
  11. Clouse WD, Hallett JW, Schaff HV, et al. Acute aortic dissection: population-based incidence compared with degenerative aortic aneurysm rupture. Mayo Clin Proc. 2004;79:176–180
  12. Hagan PG, Nienaber CA, Isselbacher EM, et al. The international registry of acute aortic dissection (IRAD): new insights into an old disease. JAMA. 2000;283(7):897–903
  13. Wanhainen A, Lundkvist J, Bergqvist D, et al. Cost-effectiveness of screening women for abdominal aortic aneurysm. J Thorac Cardiovasc Surg. 2006;132:379–385
  14. Gillum RF. Epidemiology of aortic aneurysm in the United States. J Clin Epidemiol. 1995;48:1289–1298
  15. Best VA, Price JF, Fowkes FG. Persistent increase in the incidence of abdominal aortic aneurysm in Scotland, 1981-2000. Br J Surg. 2003;90:1510–1515
  16. Reitsma JB, Pleumeekers HJ, Hoes AW, et al. Increasing incidence of aneurysms of the abdominal aorta in The Netherlands. Eur J Vasc Endovasc Surg. 1996;12:446–451
  17. Filipovic M, Goldacre MJ, Roberts SE, et al. Trends in mortality and hospital admission rates for abdominal aortic aneurysm in England and Wales, 1979-1999. Br J Surg. 2005;92:968–975
  18. Fedak PM, David TE, Borger M, et al. Bicuspid aortic valve disease: recent insights in pathophysiology and treatment. Exp Rev Cardiovasc Ther. 2005;3:295–308
  19. Ward C. Clinical significance of the bicuspid aortic valve. Heart. 2000;83:81–85
  20. Centers for Disease Control. National Center for Injury Prevention and Control. http://webapp.cdc.gov/cgi-bin/broker.exe
  21. Morales DL, Quin JA, Braxton JH, et al. Experimental confirmation of effectiveness of fenestration in acute aortic dissection. Ann Thorac Surg. 1998;66(5):1679–1683
  22. Von Kodolitsch Y, Schwartz AG, Nienaber CA. Clinical prediction of acute aortic dissection. Arch Intern Med. 2000;160:2977–2982
  23. Ohlmann P, Faure A, Morel O, et al. Diagnostic and prognostic value of circulating D-dimers in patients with acute aortic dissection. Crit Care Med. 2006;34(5):1358–1364
  24. Spittell PC, Spittell JA, Joyce JW, et al. Clinical features and differential diagnosis of aortic dissection: experience with 236 cases (1980 through 1990). Mayo Clin Proc. 1993;68:642–651
  25. Von Kodolitsch Y, Nienaber CA, Dieckmann C, et al. Chest radiography for the diagnosis of acute aortic syndrome. Am J Med. 2004;116:73–77
  26. Fradet G, Jamieson WR, Janusz MT, et al. Aortic dissection: current expectations and treatment (Experience with 258 patients over 20 years). Can J Surg. 1990;33(6):465–469
  27. Nienaber CA, Eagle KA. Aortic dissection: new frontiers in diagnosis and management: Part I: from etiology to diagnostic strategies. Circulation. 2003;108:628–635
  28. Meszaros I, Morocz J, Szlavi J, et al. Epidemiology and clinicopathology of aortic dissection. Chest. 2000;117(5):1271–1278
  29. Sanz J, Einstein J, Fuster V. Acute aortic dissection: anti-impulse therapy. In:  Elefteriades JA editors. Acute Aortic Disease. New York: Informa Healthcare; 2007;
  30. Gerber O, Heyer EJ, Vieux U. Painless dissections of the aorta presenting as acute neurologic syndromes. Stroke. 1986;17:644–647
  31. Danias P. Imaging of aneurysms and dissections: chest X-ray, echo, computed tomography, magnetic resonance imaging. In:  Elefteriades JA editors. Acute Aortic Disease. New York: Informa Healthcare; 2007;
  32. Elefteriades JA. Legal considerations in acute aortic diseases. In:  Elefteriades JA editors. Acute Aortic Disease. New York: Informa Healthcare; 2007;
  33. Cooley DA, DeBakey ME. Surgical considerations of intrathoracic aneurysms of the aorta and great vessels. Ann Surg. 1952;135:660
  34. Shores J, Berger KR, Murphy EA, et al. Progression of aortic dilatation and the benefit of long-term beta-adrenergic blockade in Marfan's syndrome. New Engl J Med. 1994;330(19):1335–1341
  35. Hackmann AE, LeMaire SA, Thompson RW. Long term suppressive therapy: clinical reality and future prospects. In:  Elefteriades J editors. Acute Aortic Conditions. New York: Informa Healthcare; 2007;
  36. Habashi JP, Judge DP, Holm TM, et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse mode syndrome. Science. 2006;312:117–121
  37. Achneck HE, Rizzo JA, Tranquilli M, et al. Safety of thoracic aortic surgery in the present era. Ann Thorac Surg. 2007;(in press).
  38. Elefteriades JA. What operation for acute type A dissection?. J Thorac Cardiovasc Surg. 2002;123:201–203
  39. Elefteriades JA, Hartleroad J, Gusberg RJ, et al. Long-term experience with descending aortic dissection: the complication-specific approach. Ann Thorac Surg. 1992;53:11–20discussion 20-1.
  40. Elefteriades JA, Lovoulos CJ, Coady MA, et al. Management of descending aortic dissection. Ann Thorac Surg. 1999;67:2002–2005discussion 2014-9.
  41. David TE, Ivanov J, Armstrong S, et al. Aortic valve-sparing operations in patients with aneurysms of the aortic root or ascending aorta. Ann Thorac Surg. 2002;74:S1758–S1761
  42. Yacoub MH, Gehle P, Chandrasekaran V, et al. Late results of a valve-sparing operation in patients with aneurysms of the ascending aorta and root. J Thorac Cardiovasc Surg. 1998;115:1080–1090
  43. Griepp RB, Stinson EB, Hollinngsworth JF, et al. Prosthetic replacement of the aortic arch. J Thorac Cardiovasc Surg. 1975;70:1051–1063
  44. Gega A, Rizzo JA, Johnson MH, et al. Straight deep hypothermic arrest: experience in 394 patients supports its effectiveness as a sole means of brain preservation. Ann Thorac Surg. 2007;84:759–766
  45. Taylor KM. Cardiac surgery and the brain: an introduction. In:  Smith P,  Taylor K editor. Cardiac Surgery and the Brain. London: Edward Arnold; 1993;p. 1–14
  46. Weir DL. The use of thiopental and propofol. In:  Smith P,  Taylor K editor. Cardiac Surgery and the Brain. London: Edward Arnold; 1993;p. 245–251
  47. Olivier HF, Maher TD, Liebler GA, et al. Use of the BioMedicus centrifugal pump in traumatic tears of the thoracic aorta. Ann Thorac Surg. 1984;38:586–591
  48. Hilgenberg AD. Spinal cord protection for thoracic aortic surgery. In:  Elefteriades JA editors. Diseases of the Aorta (Cardiol Clin). 1999;17:i-850.
  49. Elefteriades JA, Coady MA, Nikas DJ, et al. “Cobrahead” graft for intercostal artery implantation during descending aortic replacement. Ann Thorac Surg. 2000;69:1282–1284
  50. Coselli JS, LeMaire SA. Surgical techniques: thoracoabdominal aorta. In:  Elefteriades JA editors. Diseases of the Aorta (Cardiol Clin). 1999;17:i-850.
  51. Kouchoukos NT, Masetti P, Murphy S. Hypothermic cardiopulmonary bypass and circulatory arrest in the management of extensive thoracic and thoracoabdominal aortic aneurysms. Semin Thorac Cardiovasc Surg. 2003;15:333–339
  52. Jacobs MJ, Meylaerts SA, de Haan P, et al. Assessment of spinal cord ischemia by means of evoked potential monitoring during thoracoabdominal aortic surgery. Semin Vasc Surg. 2000;13:299–307
  53. LeMaire SA, Miller CC, Conklin LD, et al. A new predictive model for adverse outcomes after elective thoracoabdominal aortic aneurysm repair. Ann Thorac Surg. 2001;71:1233–1238
  54. Gill JB, Ruddy TD, Newell JB, et al. Determination of cardiac risk by dipyridamole-thallium imaging before peripheral vascular surgery. N Engl J Med. 1985;312:389–394
  55. Eagle KA, Coley CM, Newell JB, et al. Combining clinical and thallium data optimizes preoperative assessment of cardiac risk before major vascular surgery. Ann Intern Med. 1989;110:859–886
  56. Leppo J, Plaja J, Gionet M, et al. Noninvasive evaluation of cardiac risk before elective vascular surgery. J Am Coll Cardiol. 1987;9:269–276
  57. Raby KE, Goldman L, Creager MA, et al. Correlation between preoperative ischemia and major cardiac events after peripheral vascular surgery. N Engl J Med. 1989;321:1296–1300
  58. McCollum CH, Garcia-Rinaldi R, Graham JM, et al. Myocardial revascularization prior to subsequent major surgery in patients with coronary artery disease. Surgery. 1977;81:302–304
  59. Fleisher LA, Rosenbaum SH, Nelson AH, et al. The predictive value of preoperative silent ischemia for postoperative ischemic cardiac events in vascular and nonvascular surgery patients. Am Heart J. 1991;122:980–986
  60. Achneck H, Modi B, Shaw C, et al. Ascending thoracic aneurysms are associated with decreased systemic atherosclerosis. Chest. 2005;128:1580–1586
  61. Bendeck MP. Matrix metalloproteinases: are they antiatherogenic but proaneurysmal?. Circ Res. 2002;90:836–837
  62. Silence J, Collen D, Lijnen HR. Reduced atherosclerotic plaque but enhanced aneurysm formation in mice with inactivation of the tissue inhibitor of metalloproteinase-1 (TIMP-1) gene. Circ Res. 2002;90:897–903
  63. Parodi JC, Palmaz JC, Barone HD. Transfemoral intraluminal graft implantation for abdominal aortic aneurysms. Ann Vasc Surg. 1991;5:491–499
  64. Veith FJ, Gargiulo NJ, Ohki T. Endovascular treatment of ruptured infrarenal aortic and iliac aneurysms. Acta Chir Belg. 2003;103:555–562
  65. Brinster DR, Szeto WY, Bavaria JE. Endovascular thoracic aortic stent grafting in acute aortic catastrophes. In:  Elefteriades JA editors. Diseases of the Aorta (Cardiol Clin). 17:1999;i-850.
  66. Reed AB, Thompson JK, Crafton CJ, et al. Timing of endovascular repair of blunt traumatic thoracic aortic transections. J Vasc Surg. 2006;43:684–688
  67. Kaya A, Heijmen RH, Overtoom TT, et al. Thoracic stent grafting for acute aortic pathology. Ann Thorac Surg. 2006;82:560–565
  68. Nienaber CA, Zannetti S, Barbieri B, et al. INvestigation of STEnt grafts in patients with type B aortic dissection: design of the INSTEAD trial—a prospective, multicenter European randomized trial. Am Heart J. 2005;149:592–599
  69. Elefteriades JA, Percy A. Endovascular stenting for descending aneurysms: wave of the future or the emperor's new clothes?. J Thorac Cardiovasc Surg. 2007;133:285–288
  70. White RA, Donayre C, Walot I, et al. Abdominal aortic aneurysm rupture following endoluminal graft deployment: report of a predictable event. J Endovasc Ther. 2000;7:257–262
  71. Abraham CZ, Chuter TA, Reilly LM, et al. Abdominal aortic aneurysm repair with the Zenith stent graft: short to midterm results. J Vasc Surg. 2002;36:217–224discussion 224-5.
  72. Zarins CK, White RA, Hodgson KJ, et al. Endoleak as a predictor of outcome after endovascular aneurysm repair: AneuRx multicenter clinical trial. J Vasc Surg. 2000;32:90–107
  73. Zarins CK, White RA, Moll FL, et al. The AneuRx stent graft: four-year results and worldwide experience 2000. J Vasc Surg. 2001;33:S135–S145
  74. Sapirstein W, Chandeysson P, Wentz C. The Food and Drug Administration approval of endovascular grafts for abdominal aortic aneurysm: an 19-month retrospective. J Vasc Surg. 2001;34:180–183
  75. Stelter W, Umscheid T, Ziegler P. Three-year experience with modular stent-graft devices for endovascular AAA treatment. J Endovasc Surg. 1997;4:362–369
  76. Greenberg RK, Lawrence-Brown M, Bhandari G, et al. An update of the Zenith endovascular graft for abdominal aortic aneurysms: initial implantation and mid-term follow-up data. J Vasc Surg. 2001;33:S157–S164
  77. Broeders IA, Blankensteijn JD, Wever JJ, et al. Mid-term fixation stability of the EndoVascular Technologies endograft (EVT Investigators). Eur J Vasc Endovasc Surg. 1999;18:300–307
  78. Makaroun MS, Deaton DH. Is proximal aortic neck dilatation after endovascular aneurysm exclusion a cause for concern?. J Vasc Surg. 2001;33:S39–S45
  79. Silverberg D, Baril DT, Ellozy SH, et al. An 8-year experience with type II endoleaks: natural history suggests selective intervention is a safe approach. J Vasc Surg. 2006;44:453–459
  80. Coady MA, Rizzo JA, Hammond GL, et al. What is the appropriate size criterion for resection of thoracic aortic aneurysms?. J Thorac Cardiovasc Surg. 1997;113:476–491
  81. Lange C, Leurs LJ, Buth J, et al. Endovascular repair of abdominal aortic aneurysm in octogenarians: an analysis based on EUROSTAR data. J Vasc Surg. 2005;42:624–630
  82. Waasderp EJ, de Vries JP, Hobo R, et al. Aneurysm diameter and proximal aortic neck diameter influence clinical outcome of endovascular abdominal aortic repair: a 4-year EUORSTAR experience. Ann Vasc Surg. 2005;19:757–759
  83. Peppelenbosch N, Buth J, Harris PL, et al. Diameter of abdominal aortic aneurysm and outcome of endovascular aneurysm repair: does size matter? (A report from EUROSTAR). J Vasc Surg. 2004;39:288–297
  84. Laheij RJ, Buth J, Harris PL, et al. Need for secondary interventions after endovascular repair of abdominal aortic aneurysm (Intermediate-term follow-up results of a European collaborative registry (EUROSTAR)). Br J Surg. 2000;87:1666–1673
  85. Hobo R, Buth J EUROSTAR investigators. Secondary interventions following endovascular abdominal aortic aneurysm repair using current endografts (A EUROSTAR report). J VascSurg. 2006;43:896–902
  86. Leurs LJ, Bell R, Degrieck Y, et al. Endovascular treatment of thoracic aortic diseases: combined experience from the EUROSTAR and United Kingdom Thoracic Endograft registries. J Vasc Surg. 2004;40:670–680
  87. Peppelenbosch N, Buth J, Harris PL, et al. Diameter of abdominal aortic aneurysm and outcome of endovascular aneurysm repair: does size matter? (A report from EUROSTAR). J Vasc Surg. 2004;39:288–297
  88. Health Services/Technology Assessment Text (HSTAT). Guide to Clinical Preventative Services. 3rd Ed. Evidence Syntheses, formerly Systematic Evidence Reviews. National Library of Medicine and NCBI hstat.nlm.nih.gov(accessed 9/24/06).
  89. Davies RR, Goldstein LJ, Coady MA, et al. Yearly rupture or dissection rate for thoracic aortic aneurysms: Simple prediction based on size. Ann Thorac Surg. 2002;23:17–27
  90. Coady MA, Rizzo JA, Hammond GL, et al. What is the appropriate size criterion for resection of thoracic aortic aneurysms?. J Thorac Cardiovasc Surg. 1997;113:476–491discussion 489-91.
  91. Elefteriades JA. Beating a sudden killer. Sci Am. 2005;293:64–71
  92. Davies RR, Gallo A, Coady MA, et al. Novel measurement of relative aortic size predicts rupture of thoracic aortic aneurysms. Ann Thorac Surg. 2006;81:169–177
  93. Elefteriades JA, Rizzo JA, Coady MA, et al. Thoracic aorta. Radiology. 1999;211:889
  94. Elefteriades JA, Tranquilli M, Darr U, et al. Symptoms plus family history trump size in thoracic aortic aneurysm. Ann Thorac Surg. 2005;80:1098–1100
  95. Jondeau G, Gelorme G, Guiti C. Marfan syndrome. Rev Prat. 2002;52:1089–1093
  96. Milewicz DM, Hariyadarshi P, Avidan N. The genetic basis of thoracic aortic aneurysms and dissections. In:  Elefteriades J editors. Acute Aortic Conditions. New York: Taylor & Francis; 2007;
  97. Coady MA, Davies RR, Roberts M, et al. Familial patterns of thoracic aortic aneurysms. Arch Surg. 1999;134:361–367
  98. Albornoz A, Coady MA, Roberts MR, et al. Familial thoracic aortic aneurysms and dissections—incidence, modes of inheritance, and phenotypic patterns. Ann Thorac Surg. 2006;82:1400–1406
  99. Milewicz DM, Michael K, Fisher N, et al. Fibrillin-1 (FBN1) mutations in patients with thoracic aortic aneurysms. Circulation. 1996;94:2708–2711
  100. Putnam EA, Zhang H, Ramirez F, et al. Fibrillin-2 (FBN2) mutations result in the Marfan-like disorder, congenital contractural arachnodactyly. Nat Genet. 1995;11:456–458
  101. Hasham SN, Lewin MR, Tran VT, et al. Nonsyndromic genetic predisposition to aortic dissection: a newly recognized, diagnosable, and preventable occurrence in families. Ann Emerg Med. 2004;43:79–82
  102. Hasham SN, Willing MC, Guo DC, et al. Mapping a locus for familial thoracic aortic aneurysms and dissections (TAAD2) to 3p24-25. Circulation. 2003;107:3184–3190
  103. Wang Y, Barbacioru CC, Shiffman D, et al. Gene expression signature in peripheral blood detects thoracic aortic aneurysm. PLoS ONE. 2007;2:e1050
  104. Borger MA, Preston M, Ivanov J, et al. Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve?. J Thorac Cardiovasc Surg. 2004;128:677–683
  105. Russo CF, Mazzetti S, Caratti A, et al. Aortic complications after bicuspid aortic valve replacement: long-term results. Ann Thorac Surg. 2002;74:S1773–S1776
  106. Ward C. Clinical significance of the bicuspid aortic valve. Heart. 2000;83:81–85
  107. Fedak WM, David TE, Borger M, et al. Bicuspid aortic valve disease: recent insights in pathophysiology and treatment. Exp Rev Cardiovasc Ther. 2005;3:295–308
  108. Braverman AC, Guven H, Beardslee MA, et al. The bicuspid aortic valve. Curr Probl Cardiol. 2005;30:470–522
  109. Gleason TG. Heritable disorders predisposing to aortic dissection. Semin Thorac Cardiovasc Surg. 2005;17:274–281
  110. Garg V. Molecular genetics of aortic valve disease. Curr Opin Cardiol. 2006;21:180–184
  111. Cecconi M, Nistri S, Quarti A, et al. Aortic dilatation in patients with bicuspid aortic valve. J Cardiovas Med (Hagerstown). 2006;7:11–20
  112. Sans-Coma V, Fernandez B, Duran AC, et al. Fusion of valve cushions as a key factor in the formation of congenital bicuspid aortic valves in Syrian hamsters. Anat Rec. 1996;244:490–498
  113. Brinckerhoff CE, Matrisian LM. Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol. 2002;3:207–214
  114. Hackmann AE, LeMaire SA, Thompson RW. Long term suppressive therapy: clinical reality and future prospects. In:  Elefteriades J editors. Acute Aortic Conditions. New York: Taylor & Francis; 2007;
  115. Brophy CM, Marks WH, Reilly JM, et al. Decreased tissue inhibitor of metalloproteinases (TIMP) in abdominal aortic aneurysm tissue: a preliminary report. J Surg Res. 1991;50:653–657
  116. Thompson RW, Parks WC. Role of matrix metalloproteinases in abdominal aortic aneurysms. Ann NY Acad Sci. 1996;800:157–174
  117. Mao D, Lee JK, VanVickle SJ, et al. Expression of collagenase-3 (MMP-13) in human abdominal aortic aneurysms and vascular smooth muscle cells in culture. Biochem Biophys Res Commun. 1999;261:904–910
  118. Koullias G, Korkolis D, Ravichandran P, et al. Increased tissue microarray MMP expression favors proteolysis in thoracic aortic aneurysms and dissections. Ann Thorac Surg. 2004;78:2106–2111
  119. Schonbeck U, Sukhova GK, Gerdes N, et al. T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm. Am J Pathol. 2002;161:499–506
  120. Tang PC, Yakimov AO, Teesdale MA, et al. Transmural inflammation by interferon-gamma-producing T cells correlates with outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysms. FASEB J. 2005;19:1528–1530
  121. Mizuguchi T, Collod-Beroud G, Akiyama T, et al. Heterozygous TGFBR2 mutations in Marfan syndrome. Nat Genet. 2004;36:855–860
  122. Loeys BL, Chen J, Neptune ER, et al. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet. 2005;37:275–281
  123. Lopez-Candales A, Holmes DR, Liao S, et al. Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms. Am J Pathol. 1997;150:993–1007
  124. Rowe VL, Stevens SL, Reddick TT, et al. Vascular smooth muscle cell apoptosis in aneurysmal, occlusive, and normal human aortas. J Vasc Surg. 2000;31:567–576
  125. Henderson EL, Geng YJ, Sukhova GK, et al. Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms. Circulation. 1999;99:96–104
  126. Jacob MP, Badier-Commander C, Fontaine V, et al. Extracellular matrix remodeling in the vascular wall. Pathol Biol (Paris). 2001;49:326–332
  127. Liao S, Curci JA, Kelley BJ, et al. Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms compared to the adjacent inferior mesenteric artery. J Surg Res. 2000;92:85–95
  128. Koullias G, Modak R, Tranquilli M, et al. Mechanical deterioration underlies malignant behavior of aneurysmal human ascending aorta. J Thorac Cardiovasc Surg. 2005;130:677–683
  129. Elefteriades JA, Hatzaras I, Tranquilli MA, et al. Weight lifting and rupture of silent aortic aneurysms. JAMA. 2003;290:280
  130. Hatzaras I, Tranquilli M, Coady M, et al. Weight lifting and aortic dissection: more evidence for a connection. Cardiology. 2007;107:103–106
  131. Hatzaras IS, Bible JE, Koullias GJ, et al. Role of exertion or emotion as inciting events for acute aortic. Am J Cardiol. 2007;100:1470–1472
  132. Stock G. Redesigning Humans: Our Inevitable Genetic Future. Boston, MA: Houghton Mifflin; 2002;

 The author has no conflicts of interest to disclose.

PII: S0146-2806(08)00016-9

doi: 10.1016/j.cpcardiol.2008.01.004

Current Problems in Cardiology
Volume 33, Issue 5 , Pages 203-277 , May 2008

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