Foreword

Article Outline

• Copyright

Marfan Syndrome is the most common inherited disorder of connective tissue that affects multiple organ systems with an incidence of 2-3 per 10,000 individuals. Even within the same family that shares a unique mutation there is widespread phenotypic variability with regards to age of onset and the various manifestations of the disorder.

It is very important to be adept at recognizing Marfan Syndrome. Early diagnosis and appropriate management is paramount because these patients are at risk for life-threatening cardiovascular complications—aortic dissection and rupture.

Both Drs. Connolly and Sundt are Co-directors of The Marfan and Thoracic Aortic Clinic at the Mayo Clinic. This article provides an understanding of the molecular genetics, clinical features, diagnosis, and management of this disorder.

The Editors and I are grateful to Drs. Ammash, Connolly, and Sundt for this outstanding article and to Dr. Alan C. Braverman^⁎ for insightful comments.

• ⁎ Alan C. Braverman, MD, FACC, is Professor of Medicine, Cardiovascular Division, Department of Medicine, Washington University School of Medicine and Director, Marfan Syndrome Clinic, Director, Inpatient Cardiology Firm, Barnes-Jewish Hospital, St. Louis, MO.