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Current Problems in Cardiology
Volume 31, Issue 7
, Pages 445-486
, July 2006
Pathophysiology, Diagnosis, and Management of Dyslipidemia
References
-
.
Intensive statin therapy—a sea change in cardiovascular prevention
.
New Engl J Med
. 2004;350:15
-
.
Lipid-lowering Agents
.
In:
Murphy J
editors.
Mayo Clinic Cardiology Review
. 2nd Ed.. Philadelphia, PA: Lippincott Williams & Wilkins; 2000;p. 1301–1318
- . The underused miracle drugs (the statin drugs are to atherosclerosis what penicillin was to infection disease) . Am J Cardiol . 1996;78:377–378
- Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines . Circulation . 2004;110:227–239
- . On the waves of the Seven Countries Study (a public health perspective on cholesterol) . Eur Heart J . 1999;20:796–802
- . Statins do more than just lower cholesterol . Lancet . 1996;348(9034):1079–1082
- . Molecular bases of the acute coronary syndromes . Circulation . 1995;91(11):2844–2850
- A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis . Circulation . 1995;92(5):1355–1374
- . Mechanisms leading to myocardial infarction (insights from studies of vascular biology) . Circulation . 1994;90:2126–2146
-
.
Atherosclerosis
(the road ahead)
.
Cell
. 2001;14:503–516
- Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP-III) . JAMA . 2001;285:2486–2497
- . On the waves of the Seven Countries Study—a public health perspective on cholesterol . Eur Heart J . 1999;20:796–802
- . Update on statins 2003 . Circulation . 2004;110:886–892
- Prevention of coronary artery disease with pravastatin in men with hypercholesterolemia . N Engl J Med . 1995;333:1301–1307
- Randomized trial of cholesterol lowering in 4444 patients with coronary artery disease (the Scandinavian Simvastatin Survival Study (4S)) . Lancet . 1994;344:1383–1389
-
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
.
N Engl J Med
. 1996;335:1000–1009
- . Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels . N Engl J Med . 1998;339:1349–1357
- Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels (results of AFCAPS/TexCAPS) . JAMA . 1998;279:1615–1622
-
Pedersen TR, Kjekshus J, Pyorala K, et al. Presented at American Heart Association Annual Meeting. Circulation 1995;92(8):1-672, abstract no. 3225.
- Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction . N Engl J Med . 1998;339:229–234
- Apolipoproteins versus lipids as indices of coronary risk and as targets for statin treatment . Lancet . 2003;361:777–780
- . Measurement issues related to lipoprotein heterogeneity . Am J Cardiol . 2002;90(8A):22i–29i
- . Rhabdomyolysis and HMG-CoA reductase inhibitors . Ann Pharmacother . 2001;35:1096–1107
- . Glucuronidation of statins in animals and humans (a novel mechanism of statin lactonization) . Drug Metab Dispos . 2002;30:505–512
- Effects of fibrates on metabolism of statins in human hepatocytes . Drug Metab Dispos . 2002;30:1280–1287
- ACC/AHA/NHLBI clinical advisory on the use and safety of statins . Circulation . 2002;106:1024–1028
-
.
Statin-associated myopathy
.
JAMA
. 2003;289:1682–1690
- . Current overview of statin-induced myopathy . Am J Med . 2004;116:408–416
- Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans . Clin Pharmacol Ther . 1995;57:62–66
-
Statin-associated myopathy with normal creatine kinase levels
.
Ann Intern Med
. 2002;137:581–585
- . The role of carnitine supplementation during valproic and therapy . Ann Pharmacother . 2003;34:630–638
-
Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy
.
Proc Natl Acad Sci USA
. 1989;86:2379–2382
- . Pase signaling pathways in the morphological changes associated with apoptosis . Cell Death Differ . 2002;9:493–504
- . An essential role for Rho, Rad, and Cdc42 GTPases in cell cycle progression through G1 . Science . 1995;269:1270–1272
-
ACC/AHA/NHLBI Clinical Advisory on the use of safety of statins
.
Circulation
. 2002;1024–1028
- . Selenoprotein synthesis and side-effects of statins . Lancet . 2004;363:892–894
- Safety and tolerability of pravastatin in long-term clinical trials (prospective pravastatin pooling (PPP) project) . Circulation . 2002;105:2341–2346
-
.
Stating-induced myopathy
.
JAMA
. 2003;289:1682–1690
- . Cerivastatin and reports of fatal rhabdomyolysis . N Engl J Med . 2002;346:539–540
-
Data file—personal communication and package insert data. AstraZeneca LP, Alderley Park, Macclesfield, Cheshire, UK; 1998-2003.
- Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR Trial) . Am J Cardiol . 2003;92(2):152–160
- Rosuvastatin improves the atherogenic and atheroprotective lipid profiles in patients with hypertriglyceridemia . Coron Artery Dis . 2004;15:115–123
- Comparative effects of rosuvastatin and atorvastatin across their dose ranges in patients with hypercholesterolemia and without active arterial disease . Am J Cardiol . 2003;91(1):33–41
- Comparison of rosuvastatin versus atorvastatin in patients with heterozygous familial hypercholesterolemia . Am J Cardiol . 2003;92:1287–1293
- Comparison of the dose-response relationships of two lipid-lowering agents (a Bayesian meta-analysis) . Am Heart J . 2003;145(6):1036–1045
- . MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals (a randomized placebo-controlled trial) . Lancet . 2002;360:7–22
- Intensive versus moderate lipid-lowering with statins after acute coronary syndromes . N Engl J Med . 2004;350:1495–1504
- Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis (a randomized controlled trial) . JAMA . 2004;291:1071–1080
- . Comparative evaluation of the safety and efficacy of HMG-CoA reductase inhibitor monotherapy in the treatment of primary hypercholesterolemia . Ann Pharmacother . 1995;29:743–759
- Expanded Clinical Evaluation of Lovastatin (EXCEL) study results. I. Efficacy in modifying plasma lipoproteins and adverse event profile in 8245 patients with moderate hypercholesterolemia . Arch Intern Med . 1991;151:43–49
- . Benefits and risks of HMG-CoA reductase inhibitors in the prevention of coronary heart disease (a reappraisal) . Drug Saf . 1996;14:11–24
- . Nonalcoholic fatty liver disease . N Engl J Med . 2002;346:1221–1231
-
Effects of fibrates on metabolism of statins in human hepatocytes
.
Am Soc Pharm Exp Ther
. 2002;30(11):1280–1287
- Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia . Eur Heart J . 2003;24:729–741
- Inhibition of intestinal cholesterol absorption by ezetimibe in humans . Circulation . 2002;106:1943–1948
- Efficacy and safety of ezetimibe added to ongoing statin therapy for treatment of patients with hypercholesterolemia . Am J Cardiol . 2002;90:1084–1091
- . Efficacy and safety of a potent new selective cholesterol absorption inhibitor, in ezetimibe, in patients with primary hypocholesterolemia . Am J Cardiol . 2002;90:1092–1097
- Ezetimibe co-administered with simvastatin in patients with primary hypercholesterolemia . J Am Coll Cardiol . 2002;40:2125–2134
-
.
Two more drugs for dyslipidemia
.
Am J Card
. 2004;93:809–811
- Effect of coadministration of ezetimibe and simvastatin on high-sensitivity c-reactive protein . Am J Cardiol . 2003;92:1414–1418
-
Zema MJ, Chan E. Ezetimibe and colesevelam are additive in the management of hypercholesterolemia. Presented at the American College of Chest Physicians meeting 2004, abstract.
- Cholesterol-lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women (a randomized controlled trial) . Mayo Clin Proc . 1999;74(12):1198–1206
-
.
Increasing HDL cholesterol levels
.
N Engl J Med
. 2004;350:15;
1491-4
- N Engl J Med . 2004;350(15):1505–1515
- Effect of recombinant Apo A1 milano on coronary atherosclerosis in patients with acute coronary syndromes (a randomized controlled trial) . JAMA . 2003;290:2292–2300
- Inhibition of arterial thrombus formation by Apo A1 milano . Arterioscler Thromb Vasc Biol . 1999;19:378–383
- Effect of concomitant or very early statin administration on in-hospital mortality and reinfarction in patients with acute myocardial infarction . Am J Cardiol . 2001;87:771–774
-
Early statin use in acute myocardial infarction is associated with a reduced hospital mortality
(results of the Mitra-2)
.
Circulation
. 2000;102:II-435
- . Early statin treatment following acute myocardial infarction and 1-year survival . JAMA . 2001;285:430–436
-
Differential benefit from treatment with a statin agent at hospital discharge in non-ST elevation MI compared to ST elevation MI
.
Circulation
. 2000;102(suppl 2):II-614;
[Abstract 2977]
- Effect of lipid lowering therapy on early mortality after acute coronary syndromes (an observational study) . Lancet . 2001;357:1063–1068
-
Lipid lowering drug therapy initiated during hospitalization for acute MI is associated with lower post-discharge 1-year mortality
.
J Am Coll Cardiol
. 2001;37(suppl A):316A;
[Abstract 1053-91]
-
Early statin therapy is associated with markedly lower mortality in patients with acute coronary syndromes
(observations from OPUS-TIMI 16)
.
J Am Coll Cardiol
. 2001;37(suppl A):334A;
[Abstract 831-2]
-
Early statin use after acute coronary syndromes (ACS) and outcomes at 90 days
.
Circulation
. 2001;104:II-343
- Early use of pravastatin in patients with acute myocardial infarction undergoing coronary angioplasty . Acta Cardiol . 2002;57:295–302
-
Van Boven AJ, Liem A. Effects of fluvastatin administration immediately after an acute myocardial infarction on myocardial ischemia (FLORIDA). Presented at: American Heart Association Scientific Session 2000; November 12-15, 2000; New Orleans, LA. Available at: http://www.acc.org/education/online/trials/aha00/florida.htm
- Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes (the MIRACL study) . JAMA . 2001;285(13):1711–1718
- Beneficial effects of pravastatin (+/−colestyramine/niacin) initiated immediately after a coronary event (the randomized Lipid-Coronary Artery Disease [L-CAD] Study) . Am J Cardiol . 2000;86:1293–1298
- Statin lipid-lowering therapy for acute myocardial infarction and unstable angina (efficacy and mechanism of benefit) . Mayo Clin Proc . 2002;77:1085–1092
- The A-to-Z Trial (methods and rationale for a single trial investigating combined with use of a low-molecular-weight heparin with the glycoprotein IIb/III inhibitor tirofiban and defining the efficacy of early aggressive simvastatin therapy) . Am Heart J . 2001;142:211–217
- A randomized trial comparing primary angioplasty with a strategy of short-acting thrombolysis and immediate planned rescue angioplasty in acute myocardial infarction (the PACT trial) . J Am Coll Cardiol . 1999;34(7):1963–1965
- Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes . JAMA . 2004;292(11):1307–1316
-
Use of lipid-lowering medications at discharge in patients with acute myocardial infarction
(data from the National Registry of Myocardial Infarction 3)
.
Circulation
. 2001;103(1):38–44
- Superior short-term cholesterol control and achievement of the adult treatment panel III low-density lipoprotein goals with initiation of statin therapy by the time of hospital discharge following acute myocardial infarction . Am J Cardiol . 2004;93:776–779
- . Antiatherothrombotic properties of statins. Implications for cardiovascular event reduction . JAMA . 1998;279:1643–1650
- . Statins do more than lower cholesterol . Lancet . 1996;348:1079–1082
- Preprocedural statin medication reduces the extent of periprocedural non-Q wave myocardial infarction . Circulation . 2002;106:2180–2183
-
Reduced creatine kinase release with statin use at the time of myocardial infarction
.
Intl J Card
. 2004;96(3):461–466
- Upregulation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors . Circulation . 1998;97:1129–1135
- Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA) (a multicentre randomized controlled trial) . Lancet . 2003;361:1149–1158
- . Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin versus usual care. The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT-LLT) . JAMA . 2002;288:2998–3007
- . Relation of high lipoprotein(a) to other traditional atherosclerotic risk factors in patients with coronary heart disease . Am J Cardiol . 2003;91:1360–1363
- Report of the National Heart, Lung, and Blood Institute Workshop on lipoprotein(a) and cardiovascular disease (recent advances and future directions) . Clin Chem . 2003;49:1785–1896
- . Lipoprotein A. New insights into mechanisms of atherogenesis and thrombosis . Clin Cardiol . 2004;27:258–264
- Elevated plasma lipoprotein(a) and coronary heart disease in men aged 55 years and younger—a prospective study . JAMA . 1996;276:544–548
-
Long term statin treatment reduces lipoprotein(a) concentrations in heterozygous familial hypercholesterolaemia
.
Heart
. 2003;89:893–896
- Effects of lowering elevated LDL cholesterol on the cardiovascular risk of lipoprotein(a) . JAMA . 1995;274(22):1771–1774
- Estrogen and progestin, lipoprotein(a), and the risk of recurrent coronary heart disease events after menopause . JAMA . 2000;283:1845–1852
- . The association of homocysteine and coronary artery disease . Clin Cardiol . 2003;26:563–568
- . Serum homocysteine and the severity of coronary artery disease . Thromb Res . 2003;111:55–57
- Association of elevated homocysteine levels with a higher risk of recurrent coronary events and mortality in patients with acute myocardial infarction . Arch Intern Med . 2003;163:1933–1937
- Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease . Atherosclerosis . 2003;167:205–214
- Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels . Circulation . 1998;98:839–844
-
Long-term effects of pravastatin on plasma concentration of C-reactive protein
.
Circulation
. 1999;100(3):230–235
- Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events . N Engl J Med . 2001;344:1959–1965
- C-reactive protein levels and outcomes after statin therapy . N Engl J Med . 2005;352:20–28
- Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol . N Engl J Med . 1999;341:410–418
Disclosures: Gerald T. Gau, MD, Principle investigator in the COURAGE Trial and a member of the Executive Committee, was supported by the Department of Veterans Affairs Cooperative Studies Program, in collaboration with the Canadian government CIHR. R. Scott Wright, MD, received research support from Bayer, Bristol-Myers Squibb, Merck, and Johnson & Johnson and worked as a consultant for Pfizer and Merck-Schering Plough.
PII: S0146-2806(06)00036-3
doi: 10.1016/j.cpcardiol.2006.03.001
© 2006 Mosby, Inc. All rights reserved.
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Current Problems in Cardiology
Volume 31, Issue 7
, Pages 445-486
, July 2006
